College of Science - Biological Sciences
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- +82-31-290-7002
- chkimbio@skku.edu
- Natural Sciences 2 1F 32103
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Research Interest
Research interests are the field of glycomics and glycobiology, expecially on sphingolipid, ceramide and sialic acid-containing sphingolipids, ganglioside. Academic findings: Hepatic B Viral hepatocarcinoma and PTEN (Cancer Res 2003), asialo-1 acid glycoprotein in liver cirrhosis and carcinoma (Hepatol Res, 2003), GlcNAc:βMan1,4GlcNAcT-III in hepatitis (Glycoconj J, 2003), MMP-9/2 and α-fetoproteins in HBV hepatitis (J. Gastroent Hepatol 2004), HBV metastatic (FASEB J. 2004), Hepatic GnT-V and GnT-III-ApoB100 (JBC. 2004), Disialo GD3 in VSMC (JBC. 2004), therapeutic hepatocarcinoma cells (FASEB J. 2004), TG-2 in leukemia (FEBS Lett. 2004), N-GlcNAcT-III in HBV (J Gastroent Hepatol, 2004), Monosialyl GM3 in leukemic differentiation (Glycobiology 2005), MMP-9 in IVF (British J Obstetrics and Gynecol. 2005), disialo GD3 Fas-T cells (Glycobiology 2006), GM3 in PTEN (Glycobiology 2006), ROS in sialic GD3-cell (FASEB J 2006), AP-2a in GM3-PTEN (Glycobiology 2008), sialidase in leukemia (BBA 2008), GM3-VEGFR-2 interaction (Glycobiology 2009), GD3 in breast cancer (Biological Chemistry 2009), pig CMAH and N-glycolylneuraminic acid (Biochem J 2010), pST6GalNAc IV for Neu5Aca2-3Galb1-3GalNAc (Glycoconj J 2011), GM3 in TGF-β1-induced EMT (Biochem J. 2013), VEGFR-2 in neovascularization (J Mol Medicine 2013), monosialyl GM3 (Plos One 2014) and TGF-receptor (Int. J. of Biochem. Cell Biol. 2014), Sialyl Le A/X of HBx (Mol Cancer 2014, J Cell Biochem 2015). Housekeeping promoter 5'pcmah-2 of CMP-NeuGc gene (Glycoconj 2016), GD1b Apoptosis of MCF-7 (IJMS 2016), Human ST8Sia VI (α2,8-Sialyltransferase) Gene (IJMS 2016), GD2-ICAMI (IJMS 2017), Sialyllactose VEGFR-2 activation, GD3/a1AR/TG2, AApoB100-GM3, GM3-macrophage (JCB, 2017, 2018), Sirt1-FcεRI- mast cell AMPK (Sci Rep, 2017), ASC/LPS (PloS One 2017), 4-o-cASC (JCB, JSMB 2018), SARS-CoV-2-sialylation. Lectin-Glycan (IJMS, 2020),CMP-NeuGc (Sci Rep 2019), AC (FP), 3-SL-sIGLEC (Glycoconj J 2020), Avc(FP, 2021, IJMS 2021).
Education
- (PhD) 1990 University of Tokyo, Tokyo, Japan
Experience
- 2006 ~ 현재 Professor, Chai, Dept. Biological Sciences, Sungkyunkwan University, Professor of SAIHST,
- 2015-2016 Visiting Scholar, The Ohio State University, USA (KC Lee)
- 2010-2011 Visiting Scholar, Glycoscience Institute, Tokai University, Japan (A. Suzuki)
- 2020-Present, Lecturer, Fukuoka Junshin University
- 1996~ 2006 Assistant Prof, Associate Prof, Full Prof and Chairman, Bioxhemistry and MOlecular Biology, College of Oriental Medicine, Dongguk University, Gyungju
- 1990~1996 Senior Researcher, Genetic Engineering Center, Korea Institute of Science and Technology, KIST (Later, Korea Research Institute of Bioscience and Biotechnology, KRIBB) and Head of Genome Program Head
- 1987~1989 Lecturer, Tokyo College of Pharmaco and Medico-Technology, Tokyo, Japan
- 2010~Present, Associate Editor, Frontiers in Pharmacology, eCAM.
- 2010 ~ Present The Peer Journal, Int J Molec Scine, Editor
- 2012 ~ Present Current Pharmaceutical Biotechnology, Co-Editor
Journal Articles
- (2024) Dawn era for revisited cancer therapy by innate immune system and immune checkpoint inhibitors. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 3
- (2024) A novel Mycobacterium Tuberculosis antigen, MTB48 enhances inflammatory response in LPS-induced RAW264.7 macrophage immune cells. MOLECULAR IMMUNOLOGY. 166, 2
- (2023) The Derivatives of Cromolyn Ameliorate the Abnormal Misfolding of Amyloid Proteins and Neuroinflammation in the Neural Cells. CURRENT MEDICINAL CHEMISTRY. 30, 39
- (2023) T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 750, 12
- (2023) Regulatory mechanism for the human glioblastoma cell-specific expression of the human GD1c/GT1a/GQ1b synthase (hST8Sia V) gene. GLYCOCONJUGATE JOURNAL. 23, 12
- (2023) Upregulation of human GD3 synthase (hST8Sia I) gene expression during serum starvation-induced osteoblastic differentiation of MG-63 cells. PLOS ONE. 18, 11
- (2023) Editorial: The innate and adaptive immune system in human urinary system.. FRONTIERS IN IMMUNOLOGY. 14, 1294869
- (2023) Editorial: Mechanisms during bacterial infection: cellular recognition, signalling, and regulation. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2023, 09
- (2023) Editorial Insights in ethnopharmacology 2022. FRONTIERS IN PHARMACOLOGY. 14, 2023
- (2023) Up-regulation of inflammatory reactions by MPT32, a secreted protein of Mycobacterium tuberculosis in RAW264.7 macrophages. JOURNAL OF CELLULAR BIOCHEMISTRY. 124, 9
- (2023) 5-Methylthiopentyl Isothiocyanate, a Sulforaphane Analogue, Inhibits Pro-inflammatory Cytokines by Regulating LPS/ATP-mediated NLRP3 Inflammasome Activation. CURRENT PHARMACEUTICAL BIOTECHNOLOGY. 24, 16
- (2023) Naturally-Occurring Tyrosinase Inhibitors Classified by Enzyme Kinetics and Copper Chelation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 24, 9
- (2022) Physiological Properties, Functions, and Trends in the Matrix Metalloproteinase Inhibitors in Inflammation-Mediated Human Diseases. CURRENT MEDICINAL CHEMISTRY. 2022, 10
- (2022) Synthesis of a- and α-series gangliosides during differentiation of leukemic HL-60 and THP-1 cells. Clinical and Translational Discovery. 2, 3
- (2022) Curcumin-mediated transcriptional regulation of human N-acetylgalactosamine-a2,6-sialyltransferase which synthesizes sialyl-Tn antigen in HCT116 human colon cancer cells. FRONTIERS IN MOLECULAR BIOSCIENCES. 9, -
- (2022) Revisited Metabolic Control and Reprogramming Cancers by Means of the Warburg Effect in Tumor Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23, 17
- (2022) Glycan-Adhering Lectins and Experimental Evaluation of a Lectin FimH Inhibitor in Enterohemorrhagic Escherichia coli (EHEC) O157:H7 Strain EDL933. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23, 17
- (2022) Molecular Research of Glycolysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23, 9
- (2022) Mycobacterium tuberculosis glycolipoprotein LprG inhibits inflammation through NF-kappa B signaling of ERK1/2 and JNK in LPS-induced murine macrophage cells. JOURNAL OF CELLULAR BIOCHEMISTRY. 123, 4
- (2022) Systemic Lectin-Glycan Interaction of Pathogenic Enteric Bacteria in the Gastrointestinal Tract. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23, 3
Publications
- (2024) Glycoimmunology in Xenotransplantation. Nature Springer. Solo
- (2022) Glycobiology of Innate Immunology. Nature Springer Publishing. Solo
- (2021) Glycosphingolipids signaling. Nature Springer. Solo
- (2020) GM3 Signaling. Nature Springer. Solo
- (2020) Ganglioside Biochemistry. Nature Springer. Solo
- (2015) Caffeic Acid Biological Properties, Structure and Health Effcts 단행본의 Chapter 5, Molecular, Pharmacological and Chemical Biology of Caffeic Acid and Derivatives 저작. Nova Science Publishers. Lead author
Patent/Intellectual Property
- 해파리 Jellyfish Hexane Extract의 인간 만성골수성백혈병, 인간 간암 및 인간 대장암 예방 및 치료제. 10-2016-0045914. 20170808. KOREA, REPUBLIC OF
- 항암제cisplatin과 ganglioside GM3 및 그 당쇄체인 a2-3sialyllactos 병용투여를 통한 종양암 효과적 치료법 개발. 10-2014-0092477. 20170607. KOREA, REPUBLIC OF
- 불가사리 추출물을 포함하는 항 비만용 조성물. 10-2013-0169197. 20150612. KOREA, REPUBLIC OF
- 돼지 CMAH 유전자 발현 프로모터 및 이를 억제하여 제조된 이종장기 이식용 돼지세포주. 10-2012-0084164 . 20141111. KOREA, REPUBLIC OF
- 불가사리 추출물을 포함하는 항 비만용 조성물. 10-2011-0020114 . 20141021. KOREA, REPUBLIC OF
- 항동맥경화활성과 혈관질환예방 및 억제활성을 갖는 저온진공으로 추출한 장어 뼈-가공부산물의 추출물및 그 제조방밥. 2014-0061007. 20140915. KOREA, REPUBLIC OF
- 안질환의 예방 또는 치료용 조성물. 2011 533097. 20140912. JAPAN
- 항산화활성을 갖는 저온진공으로 추출한 장어 뼈-가공부산물의 추출물 및 그의 제조방법. 2012-0062723. 20140526. KOREA, REPUBLIC OF
- 장어 뼈-가공부산물 분말의 콜레스테롤 개선을 위한 건강식품 조성물. 2011-0046217. 20131202. KOREA, REPUBLIC OF
- 장어추출물을 유효성분으로 함유하는 염증성 질환예방 또는 치료용 조성물. 2011-0044554. 20131001. KOREA, REPUBLIC OF
- Composition for prevention or treatment of eye diseases. PCT/kr2009/005983. 20130903. UNITED STATES
- HBV성 간암진단. 10-2008-0098522. 20120803. KOREA, REPUBLIC OF
- 안질환의 예방 또는 치료용 조성물(Compositions for Preventing or Treating of Eye Diseases). 10-2008-0102660. 20120208. KOREA, REPUBLIC OF
- 신규한 이종항원 및 그의 용도. 10-2011-0006304. 20120130. KOREA, REPUBLIC OF
- 불가시리 추출물을 유효성분으로 포함하는 MMP-9 또는 MMP-2의 과다발현에 기인한 질환의 예방 및 치료용 조성물. 10-2008-0098523. 20110802. KOREA, REPUBLIC OF
- 백혈병 예방 또는 치료용 약제학적 조성물. 10-2008-0026704. 20100701. KOREA, REPUBLIC OF
- 독활 추출물 을 주요성분으로 함유하는 동맥경화 예방 및 치료용 조성물. 10-0801511. 20080130. KOREA, REPUBLIC OF
- 단삼 추출물 및 분획물을 함유하는 동맥경화증의 예방 또는 치료용 조성물. 10-0767238. 20071009. KOREA, REPUBLIC OF
- 종양발생및 전이에 관여하는 당단백질의 당쇄변화를 측정하는 방법 (An analyzing method for measuring the changes of glycosylation in various glycoprotein). 제10-0767018호. 20071008. KOREA, REPUBLIC OF
- Method of Diagnosing the changes of pregnancy and the diagnostic kit for the same.. United States Patent US 7,060,502 B2. 20060613. UNITED STATES
Honors / Awards
- Pejidential Medal for Science and Technology 2004
Conference Paper
- (2023) ER-Golgi network glycosylation during cellular differentiation and anti-cancer and cardiovascular mechanism(s) of natural products. 38th Inte5rnational Annual Meeting in Pharmaceutical Sciences (IAMPS38). THAILAND
- (2019) e-Membranome: a database for genome-wide analysis of Escherichia coli outer-membrane proteins.. 2019한국미생물학회연합 정기학술대호. KOREA, REPUBLIC OF
- (2019) Genome-Wide Construction of Lectin-Glycan Interaction (LGI) Network in the Early Stage of Enterotoxigenic E. coli (ETEC) Infections. KMB2019 46th Annual meeting and International Symp.. KOREA, REPUBLIC OF
- (2019) Development of Membranome Database by Genome-Wide Analysis to construct Lectin-Glycan Interaction (LGI) Network in Enterohemorrhagic E. coli (EHEC) and Enterotoxigenic E. coli (ETEC).. 한국미생물학회 2019추계학술대회 제137차. KOREA, REPUBLIC OF
- (2019) A genome-wide construction of lectin-glycan interaction (LGI) network in the early stage of enterohemorrhagic E. coli (EHEC) infections.. EMBO/EMBL Symposium유럽분자생물학기구 심포지움. GERMANY
- (2017) ASCOFURANONE INHIBITS LIPOPOLYSACCHARIDE-INDUCED INFLAMMATORY RESPONSE VIA NF-KAPPAB AND AP-1, P-ERK, TNF-α, IL-6 AND IL-1β IN RAW 264.7 MACROPHAGES. 3rd International Conference on Natural Products Utilization:From Plants to Pharmacy Shelf. BULGARIA
- (2017) ESCULENTOSIDE H INHIBITS COLON CANCER MIGRATION AND INVASION BY SUPPRESSION OF MMP-9 GENE EXPRESSION VIA JNK1/2 AND NF-κB SIGNALING PATHWAY. 3rd International Conference on Natural Products Utilization:From Plants to Pharmacy Shelf. BULGARIA
- (2017) REVISITING OLDENLANDIA DIFFUSA TO ANTI-METASTATIC AND APOPTOTIC POTENTIAL IN BREAST CANCER BY ANTI-MMP-9 AND ICAM-1VIA p38 AND ERK1/2 MAPK. 3rd International Conference on Natural Products Utilization:From Plants to Pharmacy Shelf. BULGARIA
- (2017) ESCULENTOSIDE B INHIBITS LPS-STIMULATED INFLAMMATORY RESPONSE THROUGH NF-KB, ERK1/2, P38, IL-6, IL-1Β IN RAW264.7 MACROPHAGE CELLS”. 3rd International Conference on Natural Products Utilization. BULGARIA
- (2016) Carbohydrate xenoantigens in pig to human xenotransplantation. Journal of Glycobiology. UNITED STATES
- (2016) Disialyl ST8Sia I (GD3 synthase) accumulates GD2 ganglioside and suppress ICAM-1-mediated invasiveness in human breast cancer MDA-MB231 cells. Journal of Glycobiology. UNITED STATES
- (2016) Glyco Immunology, Glycans in Drug Design 분야. Journal of Glycobiology. UNITED STATES
- (2016) Identification of housekeeping basal promoter 5’pcmah-2 of pig CMP-N-acetylneuraminic acid hydroxylase gene. Journal of Glycobiology. UNITED STATES
- (2016) Intestine specific regulation of pig CMP-N-acetylneuraminic acid hydroxylase gene (pcmah) is specifically controlled by Sp1 binding sites on its promoter: 5’pcmah-1 containing exon 1a and common ORF region (exon 2 to exon 14) is intestine specific.. Journal of Glycobiology. UNITED STATES
- (2016) 해파리추출물의 항암작용 기전연구. 종양및 면역질환의 유전적치료및 연구개발 심포지움. KOREA, REPUBLIC OF
- (2016) 4-O-methyl-ascochlorin-reduced C-Myc expression promotes apoptosis of leukemia cells by an AMPK.mTOR-dependent pathway. 16th International Conference of Biochemistry and Molecular Biology. CANADA
- (2016) Suppression of C-Myc enhances p21WAF1/CIP1-mediated G1 cell cycle arrest through the modulation of ERK phosphorylation. 16th International Conference ofBiochemistry and Molecular Biology. CANADA
- (2015) Antitumor activity of eel skin mucus, containing lactose-recognizing molecules, on human leukimic cancer cells. International Conference of the Korean Society for Molecular and Cellular Biology. KOREA, REPUBLIC OF
- (2015) Autophagy by dendropanoxide can either rpress or promote cell death in colon cancer cells. International Conference of the Korean Society for Molecular and Cellular Biology. KOREA, REPUBLIC OF
- (2014) Natural compound dendropanoxide-induced autophagy can either suppress or promote cell death in colon cancer cell lines. Journal of Biotechnology and Biomaterials. SPAIN